TY - JOUR AU - Y. V. Duda PY - 2019/09/18 Y2 - 2024/03/28 TI - The effect of Treponema Cuniculi on the cellular immunity of rabbits JF - Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology JA - SCIVP VL - 20 IS - 2 SE - Immunology and morphology DO - 10.36359/scivp.2019-20-2.28 UR - https://scivp-journal.com.ua/index.php/journal/article/view/29 AB - The spirochetosis of rabbits is widespread and affects animals in size of from 3-5  to 30 % and sometimes even 90 % in individual rabbit breeding farms.The experimental part of the work was performed in LLC “Albest” of the Dnepropetrovsk region during 2016-2019. The study was conducted on male rabbits of California breed of 3-4 months of age, weighing 3.5-4.0 kg selected on the basis of analogs. In order to determine the level of infection of rabbits by Treponema cuniculi, their excrement was investigated by the MacMaster method and divided into two groups: healthy animals (control group) and sick animals (research group). The count of T-and B-lymphocytes was determined by the method of spontaneous rosette-formation with sheep erythrocytes. Spirochetosis in male rabbits caused significant changes in the count of T- and B-lymphocytes. It was established that an increase in the number of lymphocytes was observed in the blood of rabbits with spirochetosis, mainly because of a possible increase in B-lymphocytes by 30.57 % (p <0.001). In the blood of animals of the experimental groups, there was an increase in the number of T-lymphocytes by 35.42 % (p <0.01) due to T-helpers, which increased by 1.82 times, which indicates the activation of the immune system of rabbits. In effected animals showed a significant decrease in O-lymphocytes to 8.07 % (p<0.001) and the percentage of T-suppressors - up to 15.00 % (p<0.01), compared with healthy ones. This redistribution in the population of T-cells led to an increasing of the immune-regulatory index in rabbits of the experimental group by 4 times than in healthy ones. Sick animals have T-active blood lymphocytes more 23.85 % than in the control one. In general, the results of studies showed that effect of the pathogen Treponema cuniculi in the blood of rabbits led to an increase in T-and B-lymphocytes , T-helper cells and T-active , against the background of a decrease in B-lymphocytes and T-suppressors. Such redistribution of lymphocyte populations suggests an immune response to parasitism of spirochaeta. ER -