TURNOVER OF ANTIMICROBIAL VETERINARY MEDICINAL PRODUCTS IN UKRAINE AS A FACTOR OF THEIR RATIONAL USE IN THE TREATMENT OF INFECTIOUS DISEASES IN ANIMALS

  • Yu. M. Kosenko State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives, 11, Donetska str., Lviv, 79019, Ukraine
  • N. V. Ostapiv State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives, 11, Donetska str., Lviv, 79019, Ukraine
  • L. E. Zaruma State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives, 11, Donetska str., Lviv, 79019, Ukraine
Keywords: ANTIMICROBIAL VETERINARY MEDICINAL PRODUCTS, SALES AMOUNTS, SALES PATTERNS, ANTIMICROBIAL CLASSES, TETRACYCLINES, PENICILLINS, SULFONAMIDE TRIMETHOPRIM.

Abstract

The procedure for manufacture, sale and rational use of antimicrobial veterinary medicinal products in veterinary medicine must comply with the national legislation, namely the Law of Ukraine “On Veterinary Medicine”. Only authorized in Ukraine veterinary medicinal products have been used in veterinary medicine as required with the recommendations stated in package leaflet, labeling and summary of the product characteristic. The article describes main principles of monitoring process sales turnover of antimicrobial veterinary medicinal products during period of study 2015-2018.

On the suggestion of the World Organization for Animal Health (OIE) at the beginning of 2016 Ukraine started collecting annual sales data (for the previous year) on antimicrobial veterinary medicinal products in food-producing and domestic animals in accordance with the Chapter 6.9. of the Terrestrial Animal Health Code, 2016; 2018.

The main goal of this study was the implementation of OIE recommendations in monitoring process by the assessment of sales patterns of antimicrobials, their influence on prudent use, in compliance with Ukrainian National Action Plan Tackling Antimicrobial Resistance, 2019. The study was conducted during four 12-month periods (from January 1 to December 31) during 2015-2018. The data in questionnaires reports were received from marketing authorization holders and distributors and collected as suggested by OIE. The specification of the amounts of the antimicrobials annual sales during 2015-2018 according route of administration and antimicrobial classes in [kg] and [%] of active ingredient were presented.

The study revealed the main high-selling classes of antimicrobials (Tetracyclines, Penicillins and Sulfonamide+Trimethoprim); the commonly used route of administration (oral ~ 90 %) and part of veterinary critically important and important antimicrobials in total sales amounts of all antimicrobial veterinary medicinal products. Macrolides occupied the main part (10,2 %) in veterinary critically important antimicrobial medicinal products; part of Aminoglycosides was ~ 4 %; Fluoroquinolones – among 2,5 - 7,14 % and part of Cephalosporins was less than 1% during all years of the study.

This study can be considered as the first step towards implementation a national monitoring system for rational and prudent use of antimicrobials in veterinary medicine.

References

Zakon Ukrainu “Pro Veterynarny Medycynu” iz zminamy zhidno iz Zakonamy (2020). – Available from: http://zakon2.rada.gov.ua/laws/show/2498-12/page [in Ukrainian].

Pro zatverdzhennya Polozhen pro derzhavnu reestraciyu vetery.narnyh preparative, kormovyh dobavok, premiksiv ta hotovyh kormiv. Postanоva Kabinetu Ministriv Ukrainy No 1349 vid 21 Lystopada 2007 (st. 27). – Available from: http://zakon3.rada.gov.ua/laws/show/1349-2007-%D0%BF [in Ukrainian].

Rozporyadzhennya Kabinetu Ministriv Ukrainu N 116-r of 06.03.2019 “Pro zatverdzhennya Natsionalnogo planu dij zhodo borotby iz stijkistuy do protymicrobnyh preparative. – Available from: https://zakon.rada.gov.ua/laws/show/116-2019-%D1%2019 [in Ukrainian].

ECDC/EFSA/EMA. (2017). ECDC/EFSA/EMA second joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals. ECDC [European Centre for Disease Prevention and Control], EFSA [European Food Safety Authority], and EMA [European Medicines Agency]. EFSA Journal 2017; 15(7):4872.

EMA/CVMP. (2015). CVMP strategy on antimicrobials 2016-2020. European Medicines Agency [EMA], Committee for Medicinal Products for Veterinary Use [CVMP]. – Available from: https://www.ema.europa.eu/documents/scientific-guideline/draft-committee-medicinal-products-veterinary-use-strategy-antimicrobials-2016-2020_en.pdf

EMA. (2019). EMA/CVMP/CHMP. Categorisation of antibiotics in the European Union. European Medicines Agency [EMA]/Committee for Medicinal Products for Veterinary Use [CVMP]/Committee for Medicinal Products for Human Use [CHMP]. Amsterdam: Available from: https://www.ema.europa.eu/en/documents/categorisation-antibiotics-used-animals-promotes-responsible-use-protect-public-animal-health_en.pdf]

EMA. (2020). Categorisation of antibiotics used in animals promotes responsible use to protect public and animal health. European Medicines Agency [EMA]. Amsterdam: Available from: https://www.ema.europa.eu/en/documents/press-release/categorisation-antibiotics-used-animals-promotes-responsible-use-protect-public-animal-health_en.pdf]

EMA/ESVAC. (2017). Sales of veterinary antimicrobial agents in 30 European countries in 2015 Trends from 2010 to 2015. European Medicines Agency [EMA]/European Surveillance of the Veterinary Antimicrobial Consumption [ESVAC]. London: Available from: https://www.ema.europa.eu/documents/report/seventh-esvac-report-sales-veterinary-antimicrobial-agents-30-european-countries-2015_en.pdf.

OIE. (2007). Interantional Committee of the OIE. (2007, May 20-25). Resolutions adopted by the International Committee of the OIE. Retrieved from List of Antimicrobials of Veterinary Importance (No XXVIII). Paris: Available from: http://www.oie.int/fileadmin/Home/eng/About_us/docs/pdf/A_RESO_2007_webpub.pdf

OIE. (2016). OIE Annual report on the use of antimicrobial agents in animals BETTER UNDERSTANDING OF THE GLOBAL SITUATION. World Organisation for Animal Health [OIE]. Paris: Available from: http://www.oie.int/fileadmin/Home/fr/Our_scientific_expertise/docs/pdf/AMR/Survey_on_monitoring_antimicrobial_agents_Dec2016.pdf.

ОІЕ. (2018). Terrestrial Animal Health Code. Сhapter 6.9 Monitoring of the quantities and usage patterns of antimicrobial agents used in food-producing animals. (Twenty-seventh edition ed., Vol. I General provisions). Paris: Available from: https://www.oie.int/index.php?id=169&L=0&htmfile=titre_1.6.htm

OIE. (2019). OIE LIST OF ANTIMICROBIAL AGENTS OF VETERINARY IMPORTANCE (July 2019). Paris: Available from: https://www.oie.int/fileadmin/Home/eng/Our_scientific_expertise/docs/pdf/AMR/A_OIE_List_antimicrobials_July2019.pdf

WHO. (2017). WHO GUIDELINES ON USE OF MEDICALLY IMPORTANT ANTIMICROBIALS IN FOOD-PRODUCING ANIMALS. World Health Organization [WHO]. Geneva: Available from: http://apps.who.int/iris/bitstream/handle/10665/258970/9789241550130-eng.pdf;jsessionid=DDCD0A19E8266F7A9CF40F71A5CC1E48?sequence=1.

Published
2020-06-01
How to Cite
Kosenko, Y. M., Ostapiv, N. V., & Zaruma, L. E. (2020). TURNOVER OF ANTIMICROBIAL VETERINARY MEDICINAL PRODUCTS IN UKRAINE AS A FACTOR OF THEIR RATIONAL USE IN THE TREATMENT OF INFECTIOUS DISEASES IN ANIMALS. Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology, 21(1), 88-97. https://doi.org/10.36359/scivp.2020-21-1.10