Investigation of acute and chronic toxicity of Ginkgo Biloba samples (Ginkgo Biloba)
The article presents the results of acute and chronic toxicity of Ginkgo Biloba specimens. It was established that in assessing the general condition of animals after 30 minutes. and 1 year after single administration of the extract at doses of 1,000, 2,500 and 5,000 mg / kg, decreased mobility of both mice and rats, which occurred at the third hour of observation. There are no other signs of intoxication, in particular from the central and autonomic nervous system (lateral position, muscle tone reduction, movement coordination, blepharoptosis, hyperalsalivation, etc.). To detect possible toxic effects of the drug on the organism of animals at 21 and 31 days from the start of the drug in 10 mice each group studied the antitoxic function of the liver with hexenal test and in the other 10 mice in each group was placed a swimming test. The appetite of all mouse experimental groups was satisfactory and did not differ from the control ones. In animals, 4 groups for 14 days, somewhat decreased motor activity. The study of emotional-behavioral reactions of white mice after administration of extracts for 14 days in a therapeutic dose did not show a significant effect on the nervous system. In mice, the fourth group of liver was increased by 1.5-2 times. The difference is also manifested in determining the color of the organ. In the control group, the first and second experimental groups, the liver is homogeneous, painted in light brown color, elastic, on the section the structure is preserved. In animals of other groups of the liver in places is heterogeneous, colored in dark brown color with dark cherry stripe. During the macroscopic examination of the spleen in animals of the fourth experimental group, the organ was slightly changed in size. In all cases, the body had an elongated shape. In mice of other groups - dark red color, the edges are sharpened, on the cut from the scraper of the pulp is insignificant. Spleen in animals of the fourth group - light red color. In the macroscopic study of the kidneys in all animal groups, the form of the organ was not altered. In this case, the consistency of organs in animals of all groups was elastic, the capsule from the kidneys was removed easily. Based on the results of the studies, Ginkgo Biloba extract with subcutaneous administration to white mice for 14 days in a therapeutic dose did not cause significant changes in the general condition, body weight, morphological and biochemical blood parameters.
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