Levels of vitamins in blood of young bulls by experimental chronic cardium toxicosis
Cadmium exposure is associated with ecological risk to the body through cumulative toxicity to organs and systems. It causes a decrease in the intensity of the growth and productivity of animals. Accumulation of this heavy metal in the components of the natural environment increases the risk of its introduction into the body and poses a threat to animal health. That is why the purpose of the work was to study the effect of cadmium load on the level of vitamins A and E in the blood of young animals of cattle. The research was carried out on the basis of the farm village. Ivanivtsi Zhydachiv district of Lviv region on ten young bulls of six months old, Ukrainian black-and-white milk breed, which were formed into two groups of five animals in each: control and experimental. Bulls of the control group were in the usual diet. Young bulls of the experimental group were fed feed with cadmium chloride at a dose of 0.04 mg / kg body weight of the animal. The study lasted for 30 days. To conduct research, the rules were followed for the implementation of zootechnical experiments on the selection and maintenance of animal-analogues in the group, harvesting technology, use and accounting of consumed feed. The animal's diet was balanced by nutrients and minerals that provided them with essential nutrients. The experiments were carried out in accordance with the principles of humanity laid down in the directive of the European Community. The results of the experiment indicate that cadmium significantly affects the metabolism of liver cells, thus stimulating the processes of lipid peroxidation and suppressing the activity of the non-limiting chain of the antioxidant system, namely the level of vitamins A and E in the blood of young cattle. The lowest level of vitamins A and E was in the blood of the experimental group of young bulls on the 20th day of the experiment, which respectively fluctuated within the range of 0.62 ± 0.035 and 2.9 ± 0.10 μmol/L. Only on the 5th day of the experiment was noted a slight increase in the content of vitamins, which is possibly due to the protective effect of the bulls organism on the intake of cadmium chloride in a toxic dose. The conducted studies made it possible to reveal more deeply the pathogenesis of the toxic effect of Cadmium on the organism of young cattle and use these data to develop an antidote for cadmium intoxication.
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