Study of safety indicators modified starch on white mice

  • A. Vovkohon Bila Tserkva National Agrarian University, Bila Tserkva, Ukraine
Keywords: modified starch, intra-gastric administration, protein, aminotransferase, protein metabolism, laboratory animals


Starch is widely used in the food industry. However, physicochemical properties make it possible to use this carbohydrate in other sectors of the national economy.  The sorption properties of starch allow of adding organic compounds to it, including enzymes and microorganism cells. The starch may act as a carrier for immobilization of microorganisms. The advantages of starch as a carrier are its availability, renewal ability and relatively low cost. In order to increase the carrier capacity of starch, a work package on its modification by physicochemical methods was carried out in the laboratory of Research Institute of food technologies and technologies of processing of livestock products at the Bila Tserkva National Agrarian University.

The use of modified starch as a carrier for the cells’ immobilization of ferment microorganisms for sour-milk products requires the study of its harmlessness.  The study was conducted on linear mice with a body weight of 19-21 g. The modified starch was used in experimental animals by intra-gastric method using a metal probe.  At the end of the experiment, the animals were slaughtered, their tissues and organs were taken for biochemical studies.

Experimentally, it was found that intra-gastric administration of 0.3 cm3 of 5.0% and 10.0% modified starch solution did not provoke any diseases or deaths of animals during experiment. The animal ethology was similar to that one of control mice. Introduction of increased doses of modified starch did not affect the external appearance of liver, spleen, kidney and digestive organs of animals.

The studies of protein metabolism data have shown that the activity of aspartate aminotransferase and alanine aminotransferase in the liver of mice fed by modified starch probably did not differ from similar data of animals fed by physiological solution. The difference in the total protein content in liver and urea in blood of experimental and control animals was not significant. Hemoglobin in blood of the mice after intra-gastric administration of different doses of the investigated factor was within limits of physiological norm.


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How to Cite
Vovkohon, A. (2019). Study of safety indicators modified starch on white mice. Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology, 20(2), 303-310.