Effect of eimerostats on biochemical and immunological indices of calves' blood serum during a mixed course of cryptosporidiosis and eimeriosis
Cryptosporidia often parasitize in combination with eimeria and helminths, which leads to a complication of therapeutic treatment measures and to an increase in the level of death among young animals. The scheme of application of medical preparations for animals, which would have high efficiency, remains uncertain. The developed medicinal product "Amprolev-plus" exhibited 100% extensive efficiency for cryptosporidiosis and 95.7 % for eimeria. Therefore, the relevant issue is still as follows: investigation into the influence of eimerostats on biochemical and immunological indices of calves’ blood serum in the mixed invasion course.
Within the experiment, 3 days after applying Brovitakoktsid and Amprelev-plus, the total protein content decreased by 0.9 % and 0.7 % and albumin by 5.1 % and 7.1 %, respectively, compared with the control group.
After applying Brovitakoktsid, content of β-globulins on the 7th day was 10,20±0,05 g/L, which is almost at the control level of 10.20±0,14 g/L, whereas indicators after applying Amprolev-plus were at the level of 9.80±0.16 g/L, i.e., decreased by 3.9 %.
After applying Brovitakoktsid on the 3rd and 7th day, the content of γ-globulins made up of 14.80±0,29 g/L and 14.20±0,10 g/L, and the indicator decreased only on the 14th day to 13.80±0.22 g/L, that is almost the control level of 13.90±0.09 g/L. After applying Amprolev-plus, the indicator gradually decreased from 13.80±0.15 g/L on the 3rd day up to 13.10±0.18 g/L on the 14th day.
Albumin/Globulin ratio formed the corresponding A/G coefficient. It was at the level of 0.7‒0.8 in the control group of animals during the entire period of research, as well as in research groups before applying drugs. After applying Brovitakoktsid, the A/G ratio made 1.0 only on the 21st day of the experiment, whereas after Amprolev-plus application the same ratio was obtained already on the 14th day.
High activity of AST and ALT transaminases was recorded in the invasive calves of both experimental and control groups. The AST activity significantly decreased by 10.2 % only on the 21st day after Brovitakoktsid application, whereas the decrease by 11.2% was observed after Amprolev-plus application on the 14th day, compared to the control.
The concentration of circulating immune complexes (CIC) on the 7th day of the experiment in the second group of animals significantly decreased by 7.5 %, while in the first group the CIC concentration decrease by 12.8 % was recorded only on the 14th day of the experiment, which indicates a reduction in the immunosuppression of preparations.
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