Efficiency of the preparation on the basis of colistine for treatment of gastrointestinal infections of piglets
The article presents the results of clinical trials of veterinary preparation on the basis of colistine (Colistovet) under the treatment of piglet’s acute gastro-intestinal diseases of bacterial etiology. The therapeutic efficiency and safety of preparation under the treatment of 2–2,5 months of age sick piglets has been proved.
Clinical trials were conducted on the base of the farm TZOV "Halych Khutro" (Velyke village, Sokalsky district, Lviv region). For the experiment piglets aged 2–2,5-months were selected. Disease of animals was characterized by acute gastrointestinal and respiratory diseases. The emergence of the disease contributed to a number of external factors, namely: early isolation from sows, regrouping, poor indoor microclimate, hypothermia, malnutrition, and the others. The diagnosis was put up by veterinary specialists of farm and DNDKI of veterinary preparations on the basis of complex analysis of epizootological data, clinical signs, pathologic-anatomical changes and results of bacteriological researches. It was found that the pathogens of the disease were gram-negative bacteria of the family of enterobacteria Klebsiella pneumoniae, sensitive to colistinum. Preparation Colistovet was administered to piglets orally with food in a dose of 200 g per 1 ton of feed daily for seven days. Laboratory blood tests for evaluation of physiological state of the piglet’s organism and biochemical homeostasis were carried out before the use of drugs and at 14 days after the use of the drug. Morpho-functional state of the piglet’s organism before and after treatment established by morphological and biochemical indices of blood that determined in accordance with generally accepted methods. The morphological (number of red blood cells, the number of white blood cells, hematocrit value, hemoglobin concentration, leukocytogram by conventional methods and biochemical (total protein concentration, creatinine, activity of ALT, AST, AP) piglet’s blood parameters were studied on biochemical analyzer Humalyzer 3000 using sets of reagents and standards firm Human.
The influence of preparation Colistovet on haematological and biochemical parameters of piglet’s blood was studied. The tendency to increasing of blood haemoglobin concentration, reliable reduction of neutrophils stab quantity and increasing of lymphocytes relative quantity were established after the drug’s application. On the basis of immunological parameters and indicators of the activity of the enzymes AlAT, AsAT, alkaline phosphatase in the serum of piglets, the positive effect of drug on the gradual restoration of the functional state of the hepatobiliary system, as well as the activation of the cellular link of nonspecific resistance in animal’s organism, was established.
The preparation Colistovet is effective during the treatment of piglets with acute gastro-intestinal diseases of bacterial etiology. This is confirmed by the improvement of their clinical condition and normalization of majority of piglet’s blood indices.
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