THE COMPARATIVE EVALUATION OF COMPLEX MEDICINES, BASED ON IMIDACLOPRIDE IN ECTOPARASITOSIS OF DOGS AND CATS
The article represents data on the effectiveness of the new domestic anti-parasitic medicine «Animal VetLine antiparasitic drops for dogs and cats spot-on» in comparison to the reference-medicine «Advantage@» when used for the therapeutic and prophylactic purposes for ectoparasites of dogs and cats of different breeds.
According to the results of clinical examination and parasitological examination of animals, parasitism of fleas of the Ctenocephalides canis, Ctenocephalides felis, Pulex irritans species at the intensity of invasion (II) from 5 to 8 specimens/10 cm2, lice Linognathus setosus at II from 1 to 3 specimens/10 cm2 of body surface, and parasitic mites of the Ixodes ricinus, Dermacentor reticulatus species at II from 8 to 12 specimens per animal in addition in dogs.
Based on the obtained results for the study of the effectiveness of the «Animal VetLine antiparasitic drops for dogs and cats spot-on» in comparison with the reference drug «Advantage@» medicine, during the infection of dogs and cats by Ctenocephalides canis, Pulex irritans and Ctenocephalides felis fleas, Linognathus setosus lice, mites of the Ixodes ricinus, Dermacentor reticulatus species, was found that on the second day of treatment in the experimental and control groups of animals there was a sharp increase in the number of dead insects, ectoparasites and Ixodes mites, and on the fifth day of the study no live fleas were detected, lice and ticks.
At the same time, on the second day after the usage of the experimental and reference drug, their extensile effectivity during the linognatosis of dogs and cats and syphonapterosis of cats was 100.0 %. In the experimental and control groups of dogs on the second day after usage of the experimental drug and the reference drug, the average intensity of invasion of Ctenocephalides canis and Pulex irritans decreased to 1.2±0.4 ectoparasite insects per 10 cm2 of body surface in the experimental group and to 1.4±0.4 insect ectoparasites per 10 cm2 of body surface in the control group of animals, ie the intensity of the experimental drug was 82.1 %, and the reference drug 78.5 %.
The results show that the rate of intensification of the drug for exodidosis of dogs in the experimental group on the second day was – 75.0 %, and the control – 68.0 %. However, the average intensity of mite infestation of the family Ixodidae was in the experimental group 2.5±0.15 specimens per animal, and in the control group 3.0±0.21 specimens per animal, respectively.
It was found that the experimental drug had no toxic effects and was well tolerated by animals no changes in clinical signs during use were detected.
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