SPECIFIC CHEMOTHERAPY DRUGS FOR DOGS WITH PYROPLASMOSIS TRANSMITTED BY IXODID TICKS
Babesiosis is a natural focal seasonal diseases of carnivorous and farm animals. For treatment of this invasion is very important etiotropic therapy, as cases of self-healing of dogs are very rare. However, the use of only etiotropic drugs does not restore hematopoiesis, liver function and heart function. The experimental part of the work was carried out on the basis of the veterinary clinic "Fauna-Service" (Kamyanets-Podilsky) during 2019-2020. The study was performed on dogs of different breeds, genders and ages spontaneously affected by babesiosis. The diagnosis was established comprehensively, based on epizootiological data, clinical signs and laboratory results.
It was identified specific clinical signs. The level of parasitaemia ranged from 1 to 3%. In the blood of dogs were recorded a decrease in erythrocytes, hemoglobin and lymphocytes relative to normal and an increase in such indicators as the number of leukocytes, alkaline phosphatase, ALT, AST, ESR, urea, creatinine, total bilirubin.
According to the results of laboratory studies conducted 7 days after the start of treatment, it was found that in the second experimental group, where "Azidine-vet" was used three times and in combination with "Phos-Bevit" and "Carsilin" hematological and biochemical parameters of blood were normalized faster than with the first group in which "Azidine-vet" was used twice. Thus, the number of erythrocytes, hemoglobin and creatinine in the first group was 4.79 ± 0.41 1012 / l, 115.67 ± 12.23 g / l and 149.46 ± 17.65 mmol / l, and in the second – 5.35 ± 0.63 1012 / l, 143.12 ± 15.23 g / l and 111.67 ± 13.73 mmol / l, respectively. Both treatment regimens provided 100% efficacy in dogs with babesiosis. "Azidine-vet" when used three times in combination with an immunomodulator and hepatoprotector provides less toxic effects on the body of dogs and faster recovery of organ and system functions than the classic double use of the drug.
Abuladze, K.I., Nikolsky, S.I., Kolabsky, N.A. (1975). Parasitology and invasive diseases of farm animals. M . Kolos. 42-65. [in Russian].
Adaszek, Ł., Martinez, A. C., & Winiarczyk, S. (2011). The factors affecting the distribution of babesiosis in dogs in Poland. Veterinary parasitology, 181(2-4). 160–165. https://doi.org/10.1016/j.vetpar.2011.03.059.
Balagura, T.V. (2000). Babesiosis of dogs (biology of the pathogen, epizootology, pathogenesis and improvement of control measures): author. dis. Cand. vet. sciences. M., 2000. 17. [in Russian].
Berezovsky, A.V. (2007). Modern drugs of pharmacological correction and chemoprophylaxis of animals. K. 138-141. [in Ukrainian].
Berezovsky, A.V., Prus M.P. (2002). Zastosuvannya azidine-vet dlya likuvannya babezioziv u sobak. Veterynarna medycyne Ukrainy. 2. 32-33. [in Ukrainian].
Galat V.F., Berezovsky A.V., Soroka N.M. that in. (2014) Global parasitology. К .: DIA. 420-508. [in Ukrainian].
Kartasheva, I.V. (2005). Epizootic features, diagnosis and therapy of canine babesiosis in Omsk: author. dis. ... cand. vet. sciences. Tyumen.18.
Kosheleva, M.I. (2006). Babesiosis of dogs in the conditions of the Moscow region: epizootology, immunity, therapy: author. dis. ... cand. vet. sciences. M., 19.
Levytska, V.A., Berezovsky, A.V., Mushinsky, A.B. (2020). Diagnosis and treatment of babesiosis in dogs, features of the use of Ukrainian therapeutic drugs. Аgrarian Bulletin of tte Black Sea Littoral. 97, 24-32. https://doi.org/10.37000/abbsl.2020.97.03[in Ukrainian].
Prus, M.P. (2006). Babesiosis of dogs (epizootology, pathogenesis and go fight): Author's abstract. dis. ... dr. vet. sciences. K. 37. [in Ukrainian].
Prus, M.P., Berezovsky, A.V., Galat, V.F., et al. (2003). Declarative patent 57244-А Ukraine, А61К31/00, 31/63. The method of complex treatment of babesiosis (pyroplasmosis) in dogs / (UA) - 20020750019; Appl. 02/05/02; Publ. 06.16.03, Bul. No. 6. [in Ukrainian].
Romel, M., Ecker, J., Kurster, E., et al. (2000). Veterinarmedizinische Parasitologie. Berlin: Parey buchverlag. 522-525.
Saipov, G.A. (2007). Babesiosis of dogs in urbanized areas: epidemiological surveillance, improvement of control measures: author. dis. ... Cand. vet. sciences. N. Novgorod. 23. [in Russian]. Shevtsov, A.A. (1983). Veterinary parasitology. K .: Vishcha shkola, 1983. 246-258. [in Ukrainian].
Taylor, М.A., Coop, R.L., Waller, R.L. (2016). Veterinary Papasitology. Ozfort. 646-648. Temichev, K.V. (2014). Improving control measures for babesiosis in dogs: author. dis. ... Cand. vet. sciences. Stavropol. 22. [in Russian].
Tretyakov, A.D. (1972). Veterinary legislation. M .: Kolos. 1. 640-643. [in Russian]. Zygner, W., Gójska-Zygner, O., Norbury, L.J., Wedrychowicz, H. (2012). Increased AST/ALT ratio in azotaemic dogs infected with Babesia canis. 15(3):483-486. doi:10.2478/v10181- 012-0074-7.
This work is licensed under a Creative Commons Attribution 4.0 International License.